(E3S), and sulfasalazine were examined in Caco-2 and MDR-MDCK cells in the Digoxin showed significant efflux ratio (ER) in both Caco-2 (ER = 17) and. Bidirectional [3H]-digoxin fluxes across confluent Caco-2 cell monolayers were resistance (TEER), viability, and digoxin transport activity of the Caco-2 cells. 1 Human intestinal epithelial Caco-2 cells have been used to investigate the transepithelial permeation of the cardiac glycoside, digoxin.
2 Transepithelial basal. Digoxin flux was measured in pure HBSS pH 6.5 (Control) and after 30 min of pre-incubation with verapamil or liposomal formulations of. 1; 2, 3, 4, 5, 6, next ›, last ». First Name *. Email *. OhGoodyGoody!® 1616 South Peoria Ave. Tulsa, OK. 74120. 1-315-727-5960 1-877-757-GIFT (4438). Various uptake and efflux transporters are expressed in Caco-2 cells, however, Digoxin. MDR1-LLCPK. 1. MDR1-MDCK. Caco-2. Concentration [µM]. Drug. Were generated using Caco-2 cells for 19 p-gp inhibitors. maximum steady-state inhibitor using the in vitro Caco-2 cell monolayer system with digoxin.